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Beneficial Effects of Corticosteroids on Ocular Myasthenia Gravis ARch Neurol 53:802-804, Kupersmith,M.J.,et al, 1996 See this aricle in Pubmed Article Abstract Diplopia,which was initially found in the primary position in 29 patient and in the downgaze position in 26 patients,was absent in 21 patients at 2 years.Generalized myasthenia gravis occurred in 3 patients at 2 years. Elevated serum acetylcholine receptor antibody levels and abnormal electromyography findings were not predictive of worsening.No patient experienced a major steroid complication.Moderate dose daily prednisone for 4 to 6 weeks followed by an low dose alternate day therapy as needed can control the diplopia in patients with ocular myasthenia gravis.The frequency of deterioration to generalized myasthenia gravis at 2 years may be reduced;9/4%in this study compared with more than 40%previously reported frequency.Corticosteroids may be useful even when ocular motor dysfunction is not normalized.

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(click to filter results - removes previous filter) diplopia myasthenia gravis myasthenia gravis,ocular steroid steroid therapy,CNS treatment and complications with treatment of neurologic disorder

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